Researchers discovered that hydroquinine, a naturally occurring chemical, has bacterial killing potential against a variety of pathogens. The findings, published in the journal Tropical Medicine and Infectious Disease, imply that the organic compound’s antibacterial capabilities make it a promising option to kill Drug-resistant bacteria.
Antimicrobial resistance has emerged as one of the most significant threats to global public health. It happens when bacteria, viruses, fungi, and parasites evolve over time and no longer react to medications, making infection treatment difficult. As a result, there is an urgent need for the development of novel antimicrobial medications to fight infections.
The Research on Hydroquinine
Scientists from the University of Portsmouth, and Naresuan and Pibulsongkram Rajabhat Universities in Thailand, conducted a new study to see if hydroquinine, which is present in the bark of some trees, may suppress any bacterial strains. Hydroquinine is previously recognised to be an efficient antimalarial agent in humans. But there has been minimal research on its drug-resistant qualities.
“Using bacterial killing assays, we discovered that hydroquinine was able to kill various germs, including the prevalent multidrug-resistant pathogen pseudomonas aeruginosa,” stated Dr Robert Baldock of the University of Portsmouth.
They also observed that one of the key methods employed by these bacteria to avoid the drug’s lethal effect was elevated after treatment, indicating a powerful response from the bacteria.
He states, “By further researching this compound, we expect to provide another treatment method for bacterial infections in the future.”
Researchers Stand on this study
Drug-resistant bacteria cause around 2.8 million infections each year and kill 35,000 people. Antibiotic-resistant “superbugs” are responsible for diseases such as sepsis, urinary tract infections, and pneumonia. Statistics suggest bloodstream infections with the bacterium — P. aeruginosa are related to significant fatality rates of between 30 and 50%.
The report suggests more research into hydroquinine’s antimicrobial resistance qualities and adverse effects.
Dr Jirapas Jongjitwimol of Naresuan University’s Department of Medical Technology added that their next study would focus on identifying the molecular target of hydroquinine. This would improve our understanding of how the molecule acts against pathogenic germs and how it may be employed in a therapeutic environment.”